Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.
Identifieur interne : 000032 ( Main/Exploration ); précédent : 000031; suivant : 000033Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.
Auteurs : S. Groeger [Allemagne] ; F. Denter [Allemagne] ; G. Lochnit [Allemagne] ; M L Schmitz [Allemagne] ; J. Meyle [Allemagne]Source :
- Infection and immunity [ 1098-5522 ] ; 2020.
Descripteurs français
- KwdFr :
- Antigène CD274 (métabolisme), Carcinomes (microbiologie), Carcinomes (métabolisme), Gencive (microbiologie), Gencive (métabolisme), Humains (MeSH), Infections à Bacteroidaceae (microbiologie), Infections à Bacteroidaceae (métabolisme), Kératinocytes (microbiologie), Kératinocytes (métabolisme), Lignée cellulaire tumorale (MeSH), Mitogen-Activated Protein Kinases (métabolisme), Parodontite (microbiologie), Parodontite (métabolisme), Paroi cellulaire (métabolisme), Porphyromonas gingivalis (métabolisme), Protéines adaptatrices de la transduction du signal (métabolisme), Receptor-Interacting Protein Serine-Threonine Kinase 2 (métabolisme), Régulation positive (physiologie), Tumeurs de la bouche (microbiologie), Tumeurs de la bouche (métabolisme).
- MESH :
- microbiologie : Carcinomes, Gencive, Infections à Bacteroidaceae, Kératinocytes, Parodontite, Tumeurs de la bouche.
- métabolisme : Antigène CD274, Carcinomes, Gencive, Infections à Bacteroidaceae, Kératinocytes, Mitogen-Activated Protein Kinases, Parodontite, Paroi cellulaire, Porphyromonas gingivalis, Protéines adaptatrices de la transduction du signal, Receptor-Interacting Protein Serine-Threonine Kinase 2, Tumeurs de la bouche.
- physiologie : Régulation positive.
- Humains, Lignée cellulaire tumorale.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (metabolism), B7-H1 Antigen (metabolism), Bacteroidaceae Infections (metabolism), Bacteroidaceae Infections (microbiology), Carcinoma (metabolism), Carcinoma (microbiology), Cell Line, Tumor (MeSH), Cell Wall (metabolism), Gingiva (metabolism), Gingiva (microbiology), Humans (MeSH), Keratinocytes (metabolism), Keratinocytes (microbiology), Mitogen-Activated Protein Kinases (metabolism), Mouth Neoplasms (metabolism), Mouth Neoplasms (microbiology), Periodontitis (metabolism), Periodontitis (microbiology), Porphyromonas gingivalis (metabolism), Receptor-Interacting Protein Serine-Threonine Kinase 2 (metabolism), Up-Regulation (physiology).
- MESH :
- chemical , metabolism : Adaptor Proteins, Signal Transducing, B7-H1 Antigen, Mitogen-Activated Protein Kinases, Receptor-Interacting Protein Serine-Threonine Kinase 2.
- metabolism : Bacteroidaceae Infections, Carcinoma, Cell Wall, Gingiva, Keratinocytes, Mouth Neoplasms, Periodontitis, Porphyromonas gingivalis.
- microbiology : Bacteroidaceae Infections, Carcinoma, Gingiva, Keratinocytes, Mouth Neoplasms, Periodontitis.
- physiology : Up-Regulation.
- Cell Line, Tumor, Humans.
Abstract
Programmed death-ligand 1 (PD-L1/B7-H1) serves as a cosignaling molecule in cell-mediated immune responses and contributes to chronicity of inflammation and the escape of tumor cells from immunosurveillance. Here, we investigated the molecular mechanisms leading to PD-L1 upregulation in human oral carcinoma cells and in primary human gingival keratinocytes in response to infection with Porphyromonas gingivalis (P. gingivalis), a keystone pathogen for the development of periodontitis. The bacterial cell wall component peptidoglycan uses bacterial outer membrane vesicles to be taken up by cells. Internalized peptidoglycan triggers cytosolic receptors to induce PD-L1 expression in a myeloid differentiation primary response 88 (Myd88)-independent and receptor-interacting serine/threonine-protein kinase 2 (RIP2)-dependent fashion. Interference with the kinase activity of RIP2 or mitogen-activated protein (MAP) kinases interferes with inducible PD-L1 expression.
DOI: 10.1128/IAI.00051-20
PubMed: 32041789
PubMed Central: PMC7171240
Affiliations:
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Groeger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany Sabine.E.Groeger@dentist.med.uni-giessen.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Denter, F" sort="Denter, F" uniqKey="Denter F" first="F" last="Denter">F. Denter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Lochnit, G" sort="Lochnit, G" uniqKey="Lochnit G" first="G" last="Lochnit">G. Lochnit</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Schmitz, M L" sort="Schmitz, M L" uniqKey="Schmitz M" first="M L" last="Schmitz">M L Schmitz</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Meyle, J" sort="Meyle, J" uniqKey="Meyle J" first="J" last="Meyle">J. Meyle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infection and immunity</title><idno type="eISSN">1098-5522</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (metabolism)</term><term>B7-H1 Antigen (metabolism)</term><term>Bacteroidaceae Infections (metabolism)</term><term>Bacteroidaceae Infections (microbiology)</term><term>Carcinoma (metabolism)</term><term>Carcinoma (microbiology)</term><term>Cell Line, Tumor (MeSH)</term><term>Cell Wall (metabolism)</term><term>Gingiva (metabolism)</term><term>Gingiva (microbiology)</term><term>Humans (MeSH)</term><term>Keratinocytes (metabolism)</term><term>Keratinocytes (microbiology)</term><term>Mitogen-Activated Protein Kinases (metabolism)</term><term>Mouth Neoplasms (metabolism)</term><term>Mouth Neoplasms (microbiology)</term><term>Periodontitis (metabolism)</term><term>Periodontitis (microbiology)</term><term>Porphyromonas gingivalis (metabolism)</term><term>Receptor-Interacting Protein Serine-Threonine Kinase 2 (metabolism)</term><term>Up-Regulation (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigène CD274 (métabolisme)</term><term>Carcinomes (microbiologie)</term><term>Carcinomes (métabolisme)</term><term>Gencive (microbiologie)</term><term>Gencive (métabolisme)</term><term>Humains (MeSH)</term><term>Infections à Bacteroidaceae (microbiologie)</term><term>Infections à Bacteroidaceae (métabolisme)</term><term>Kératinocytes (microbiologie)</term><term>Kératinocytes (métabolisme)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Mitogen-Activated Protein Kinases (métabolisme)</term><term>Parodontite (microbiologie)</term><term>Parodontite (métabolisme)</term><term>Paroi cellulaire (métabolisme)</term><term>Porphyromonas gingivalis (métabolisme)</term><term>Protéines adaptatrices de la transduction du signal (métabolisme)</term><term>Receptor-Interacting Protein Serine-Threonine Kinase 2 (métabolisme)</term><term>Régulation positive (physiologie)</term><term>Tumeurs de la bouche (microbiologie)</term><term>Tumeurs de la bouche (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>B7-H1 Antigen</term><term>Mitogen-Activated Protein Kinases</term><term>Receptor-Interacting Protein Serine-Threonine Kinase 2</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacteroidaceae Infections</term><term>Carcinoma</term><term>Cell Wall</term><term>Gingiva</term><term>Keratinocytes</term><term>Mouth Neoplasms</term><term>Periodontitis</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Carcinomes</term><term>Gencive</term><term>Infections à Bacteroidaceae</term><term>Kératinocytes</term><term>Parodontite</term><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacteroidaceae Infections</term><term>Carcinoma</term><term>Gingiva</term><term>Keratinocytes</term><term>Mouth Neoplasms</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigène CD274</term><term>Carcinomes</term><term>Gencive</term><term>Infections à Bacteroidaceae</term><term>Kératinocytes</term><term>Mitogen-Activated Protein Kinases</term><term>Parodontite</term><term>Paroi cellulaire</term><term>Porphyromonas gingivalis</term><term>Protéines adaptatrices de la transduction du signal</term><term>Receptor-Interacting Protein Serine-Threonine Kinase 2</term><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régulation positive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Programmed death-ligand 1 (PD-L1/B7-H1) serves as a cosignaling molecule in cell-mediated immune responses and contributes to chronicity of inflammation and the escape of tumor cells from immunosurveillance. Here, we investigated the molecular mechanisms leading to PD-L1 upregulation in human oral carcinoma cells and in primary human gingival keratinocytes in response to infection with <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>), a keystone pathogen for the development of periodontitis. The bacterial cell wall component peptidoglycan uses bacterial outer membrane vesicles to be taken up by cells. Internalized peptidoglycan triggers cytosolic receptors to induce PD-L1 expression in a myeloid differentiation primary response 88 (Myd88)-independent and receptor-interacting serine/threonine-protein kinase 2 (RIP2)-dependent fashion. Interference with the kinase activity of RIP2 or mitogen-activated protein (MAP) kinases interferes with inducible PD-L1 expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32041789</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-5522</ISSN><JournalIssue CitedMedium="Internet"><Volume>88</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>04</Month><Day>20</Day></PubDate></JournalIssue><Title>Infection and immunity</Title><ISOAbbreviation>Infect Immun</ISOAbbreviation></Journal><ArticleTitle>Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e00051-20</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1128/IAI.00051-20</ELocationID><Abstract><AbstractText>Programmed death-ligand 1 (PD-L1/B7-H1) serves as a cosignaling molecule in cell-mediated immune responses and contributes to chronicity of inflammation and the escape of tumor cells from immunosurveillance. Here, we investigated the molecular mechanisms leading to PD-L1 upregulation in human oral carcinoma cells and in primary human gingival keratinocytes in response to infection with <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>), a keystone pathogen for the development of periodontitis. The bacterial cell wall component peptidoglycan uses bacterial outer membrane vesicles to be taken up by cells. Internalized peptidoglycan triggers cytosolic receptors to induce PD-L1 expression in a myeloid differentiation primary response 88 (Myd88)-independent and receptor-interacting serine/threonine-protein kinase 2 (RIP2)-dependent fashion. Interference with the kinase activity of RIP2 or mitogen-activated protein (MAP) kinases interferes with inducible PD-L1 expression.</AbstractText><CopyrightInformation>Copyright © 2020 American Society for Microbiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Groeger</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany Sabine.E.Groeger@dentist.med.uni-giessen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denter</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lochnit</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitz</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Institute of Biochemistry, Member of the German Center for Lung Research, Justus-Liebig-University, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyle</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Immun</MedlineTA><NlmUniqueID>0246127</NlmUniqueID><ISSNLinking>0019-9567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D060890">B7-H1 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C423236">CD274 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C506253">RIPK2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D053475">Receptor-Interacting Protein Serine-Threonine Kinase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060890" MajorTopicYN="N">B7-H1 Antigen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016866" MajorTopicYN="N">Bacteroidaceae Infections</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002277" MajorTopicYN="N">Carcinoma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002473" MajorTopicYN="N">Cell Wall</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009062" MajorTopicYN="N">Mouth Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053475" MajorTopicYN="N">Receptor-Interacting Protein Serine-Threonine Kinase 2</DescriptorName><QualifierName UI="Q000378" 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